The history of Santa Luzia is closely tied to the Brazilian "Gold Rush" that swept through the state of Minas Gerais in the late 17th and early 18th centuries. The first settlements in the area emerged as camps for prospectors and "bandeirantes" (explorers) searching the region for precious metals. Over time, a permanent settlement formed around a chapel, presumably dedicated to Saint Lucy (Santa Luzia). The official date of the city's founding as an independent municipality is March 18, 1847, although its history as an inhabited site began much earlier.
The primary factor driving the settlement's growth and development was gold mining. Its location in one of colonial Brazil's richest mineral regions ensured an influx of population and capital. Proximity to the Rio das Velhas also played a major role in its economic life. Gradually, as the population and economic importance grew, Santa Luzia progressed from a simple settlement (arraial) to gaining official city status, strengthening its administrative and political standing in the region.
During the early stages, Santa Luzia's economy was almost entirely centered on gold extraction. The wealth generated from the mines was reflected in the cultural and social life of the community. This period was marked by the construction of colonial-style churches and buildings, some of which survive today as testaments to past prosperity. Like many towns in Minas Gerais at the time, religious life and the construction of temples were the heart of cultural identity, uniting residents and showcasing their wealth.