La Serena holds an honourable place in the chronicles of Chile as the country's second-oldest city after Santiago. The official date of foundation is recorded as 4 September 1544, when Captain Juan Bohón, under the orders of conquistador Pedro de Valdivia, established a settlement, naming it Villanueva de la Serena in honour of his hometown in Spain. The city's early history was turbulent: shortly after its founding, it was destroyed by the indigenous population, but thanks to the perseverance of the settlers, it was rebuilt in 1549 by Captain Francisco de Aguirre. It is from this moment that the continuous history of the city's development at its current location begins.
The transformation of La Serena into a significant regional hub was driven by a fortunate combination of geographical and logistical advantages:
- Strategic Position: The city served as a vital link on the maritime and overland route between Santiago and Lima, the centre of Spanish domains in South America at that time.
- Geography and Climate: Its location on coastal terraces provided a good vantage point over the ocean for defence, while proximity to the Elqui River offered access to fresh water and fertile lands.
- Trade Hub: La Serena became a key point for the shipment of copper and agricultural produce from the northern regions.
Since its resurgence, La Serena has acquired the status of an aristocratic and administrative centre. The early economy relied on agriculture in the Elqui Valley, livestock farming, and mining. The wealth and status of the city attracted the attention not only of settlers but also of famous corsairs: during the colonial era, the city endured visits from figures such as Francis Drake. The cultural character of the city was shaped under strong Spanish influence, and construction using local shell limestone, along with an abundance of churches, eventually cemented La Serena's reputation as the "City of Bell Towers".