The history of Uherské Hradiště dates back to the mid-13th century. The city was founded in 1257 by the Bohemian King Ottokar II. Initially, the settlement was named Nový Velegrad (New Velegrad), and later it became known simply as Hradiště. The modern addition "Uherské" (Hungarian) was established much later to distinguish the city from other settlements with similar names and to indicate its proximity to the historical border with Hungary.
The city's development was largely determined by its strategic position. Uherské Hradiště was established on an island in the Morava River, where the water served as a natural moat, making the settlement difficult for enemies to reach. It was created as a powerful royal fortress, intended to protect the southeastern borders of the Kingdom of Bohemia from external threats and raids.
Granting royal city status gave residents extensive privileges and tax breaks, which stimulated a rapid influx of population. Thanks to its location at the intersection of important routes and the right to hold fairs, the city soon turned into a bustling center for trade in wine, grain, and handicrafts. Alongside the economy, spiritual life also flourished, laying the foundation for the city to become the cultural heart of the Moravian Slovakia region.