The history of the city of Reynosa, located in northeastern Mexico in the state of Tamaulipas, begins in the colonial era. It was founded on 14 March 1749 by a group of Spanish colonists as part of the exploration of new lands. Initially, the settlement received the lengthy name Villa de Nuestra Señora de Guadalupe de Reynosa, borrowing part of its name from a town of the same name in Spain. Its strategic position on the banks of the Rio Grande (known in Mexico as the Rio Bravo del Norte) immediately defined its border character and future importance.
The city's destiny was inextricably linked to the mighty river. In 1802, severe flooding forced the residents to move the settlement 8 kilometres further east to higher and safer ground. In the 19th century, Reynosa found itself at the centre of events during the Mexican–American War, being occupied by American troops from 1846 to 1848. Despite these trials, the city continued to develop: initially, its economy was built on agriculture and livestock farming, but over time, its border location made it a key centre for trade.
An important stage in the making of Reynosa was receiving official city status in 1926, which highlighted its growing economic and social role in the region. From a modest colonial settlement, Reynosa transformed into a dynamic border city, the history of which reflects the key moments of development in all of northern Mexico.