The history of Santo André has two starting points, separated by centuries but closely linked to the exploration of Brazilian lands. The first settlement, known as Santo André da Borda do Campo, was founded on April 8, 1553, by Portuguese explorer João Ramalho. It was one of the first European settlements in the interior of the continent, away from the coast. Its creation was a strategic move to strengthen Portuguese influence on the plateau and interact with indigenous peoples. However, due to security and supply difficulties, the settlement was abandoned in 1560, and its residents moved to the area of the future São Paulo.
The modern city of Santo André owes its existence to the 19th century and the industrial development of the region. A key factor in its establishment was the construction in the 1860s of the São Paulo Railway, which connected the port of Santos with the state's interior. A new settlement began to form around the railway station, which was initially part of the municipality of São Bernardo. Its convenient geographical location and transport accessibility attracted industrial enterprises and a labor force to the region, primarily consisting of European immigrants.
The economy of the new settlement quickly concentrated on industry. In the early 20th century, metallurgical, chemical, and textile production developed actively here. This defined the city's cultural identity as an important industrial center. The municipality of Santo André was officially formed in 1938, inheriting its name from its 16th-century historical predecessor. Today, Santo André is an integral part of the Greater São Paulo metropolitan area and continues to play a significant role in Brazil's economic life.