The history of Bozhou, located in the Anhui province of modern China, is rooted in deep antiquity. The first settlements in this territory are linked to legendary rulers and dynasties, while written records date back to the Spring and Autumn period (770–476 BC). At that time, these lands were part of various kingdoms until they were united under the rule of the Qin Empire. It was then that Qiaoxian County (谯县) was established, becoming the administrative core of the future city.
A key factor in the rise of Bozhou was its strategic geography. The city was situated at the intersection of important land routes, which facilitated the development of trade. However, its true fame was brought by historical figures and events. The city is the birthplace of Cao Cao (155–220 AD), a distinguished military commander and the de facto ruler during the final years of the Han Dynasty, who made Qiaoxian one of the auxiliary capitals of his Kingdom of Wei. This status significantly strengthened the city's political and economic influence.
From its early years, Bozhou acquired fame as a major centre of traditional Chinese medicine. Here, one of the country's largest markets for medicinal herbs originated and flourished, operating to this day. The trade in healing plants, minerals, and other components for traditional remedies attracted merchants from all corners of the empire, shaping the unique economic and cultural character of the city. This specialization, along with its rich historical heritage, defined the development of Bozhou for many centuries to come.