The history of the city of Wuhu spans more than two and a half millennia. The first known settlements in this territory appeared around 770 BC. Officially, the county named Wuhu was established during the Han Dynasty (206 BC – 220 AD), which laid the administrative foundation for its further development. During the Three Kingdoms period (3rd century AD), the city acquired significant strategic importance while under the control of the Kingdom of Eastern Wu.
A key role in the formation of Wuhu was played by its advantageous geographical location. Situated on the southern bank of the mighty Yangtze River, the city naturally evolved into an important transport hub and trading centre. Beginning with the Ming Dynasty (1368–1644), Wuhu became one of the largest rice trading centres in China, earning the fame of being one of the "Four Great Rice Capitals". This status defined its economic specialization for many centuries and contributed to its prosperity.
Initially, the city's economy was focused on agriculture and river trade. Wuhu received a new powerful impulse for development in 1876, when it was opened to international trade as a treaty port. This event led to the appearance of European concessions in the city, which was reflected in the architecture of that time, for example, in the construction of St. Joseph's Catholic Cathedral. Opening up to external trade contributed to modernization and laid the foundation for the city's future industrial growth.