The history of Eloy Alfaro Parish, Guayaquil is inextricably linked to the industrial development of Ecuador and the growth of its largest port city, Guayaquil. The settlement on the eastern bank of the Guayas River, opposite Guayaquil, began to form actively in the 1890s. The territory officially received the status of a rural parish (parroquia rural) of the Guayaquil canton on October 16, 1902. It was named in honor of General Eloy Alfaro, the country's president and leader of the Liberal Revolution of 1895.
The key factor in the establishment and growth of the settlement was the construction of the Trans-Andean Railway, which connected Guayaquil with the capital, Quito. The main railway station was established right here on the eastern bank. Landowner José Durán Maristany also played an important role by donating land for the tracks, which is why the area also became known as Durán. Thus, its geographical position opposite the country's main port and its transformation into a key transport hub determined the fate of this district for decades to come.
In its early years, Eloy Alfaro (Durán) developed as a significant river port and railway town, with a population primarily consisting of railway workers. The territory served as an agricultural and livestock suburb of Guayaquil, but its economic profile changed over time. In the 20th century, especially during the second half, rapid industrial growth began here, and the former suburb evolved into an independent industrial and commercial center, which is now one of the largest cities in Guayas Province.