The history of the city of Gombe is inextricably linked to the formation of the emirate of the same name, which was an important political and cultural centre in the north-east of modern Nigeria. Although the emirate itself was founded back in 1804 by the Fulani leader Buba Yero, the modern city appeared much later. Initially, the capital was the city of Gombe Aba ("Old Gombe"), founded around 1824.
A key moment in the history of modern Gombe was in 1919, when the British colonial administration decided to move the capital of the emirate to a new location — the settlement of Doma, which was renamed Gombe. This event determined its further development as an important administrative centre. The status of the city was further strengthened in 1996 when it became the capital of the newly created Gombe State.
The city's economic growth was facilitated by its strategic location at the crossroads of trade routes. The opening of a railway line in 1963 turned Gombe into a major hub for the collection and shipment of agricultural produce, such as groundnuts and cotton. The fertile lands in the Gongola River basin also favoured the development of agriculture, which, along with trade and traditional crafts, formed the basis of the local economy. Culturally, the city became a melting pot for various ethnic groups, including the Fulani, Bolewa, Tera, and Hausa.