The history of the city of Denizli is closely interwoven with its famous ancient predecessor — Laodicea. Although the modern city was founded by Turkic settlers, its roots reach deep into the centuries, back to the flourishing civilizations of Anatolia.
The predecessor of modern Denizli was the ancient city of Laodicea on the Lycus (Laodicea ad Lycum), the ruins of which are located just a few kilometres to the north. Laodicea was founded in the 3rd century BC by the Seleucid King Antiochus II and named in honour of his wife, Laodice. The city quickly became one of the most important centres of Phrygia. Following devastating earthquakes and wars that led to the decline of Laodicea, a new Turkic settlement emerged nearby in the 11th–12th centuries, which eventually evolved into today's Denizli.
Several key factors contributed to the city's development. A crucial role was played by its geographical location: the city is situated in the fertile valley of the Büyük Menderes River at a strategic crossroads of trade routes connecting the Aegean coast with central Anatolia. Another factor was trade; inheriting the commercial traditions of Laodicea, Denizli became a significant hub for production and commerce. Political stability was also of great importance: throughout its history, the region was part of the Roman, Byzantine, and later the Ottoman Empires, which consolidated its status as an essential administrative centre.
Since ancient times, the region has been known as a centre of textile production. Laodicea was not only a wealthy trading and banking city but also a centre of healing, housing a renowned medical school and producing eye ointments. The city was also one of the early centres of Christianity and is mentioned in the Bible as one of the "Seven Churches of Revelation". With the formation of Denizli, these ancient traditions intertwined with Turkic culture, creating a unique heritage that can still be observed today.