Cheap flights from La Serena
The city's primary aviation hub is La Florida Airport, located just 5 kilometers from the city center. Currently, regular flights operate from here to 6 domestic routes. The most popular destinations are Santiago, with 116 departures per week, as well as Calama and Antofagasta, with a frequency of 33 and 29 flights, respectively.
Air service is provided by 3 carriers, with Latam Airlines Group and JetSmart playing the leading roles. Sky Airline also maintains a consistent flight schedule to various regions across the country. Below on this page, you will find city cards with convenient interest filters to help you navigate the route network and choose the best flight option.

La Serena — Santiago

La Serena — Concepción

La Serena — Arica

La Serena — Calama

La Serena — Antofagasta

La Serena — Iquique
Flight insights from La Serena
Data-driven trends for direct flights from La Serena — how often airlines fly, where they go, and typical fares and flight times.
Most frequent destinations
The most frequent direct destinations from La Serena are Santiago, Calama and Antofagasta. Santiago leads with around 116 flights a week.
- Santiago116 flights/week
- Calama33 flights/week
- Antofagasta29 flights/week
- Concepción8 flights/week
- Iquique4 flights/week
Direct routes & fares
Popular non-stop routes from La Serena range from Santiago at $22 to Iquique at $31 — a quick way to compare direct-flight fares.
- Santiagofrom $22
- Calamafrom $23
- Antofagastafrom $24
- Concepciónfrom $23
- Iquiquefrom $31
Cheapest destinations
The cheapest destinations from La Serena right now are Santiago from $22, Calama from $23 and Concepción from $23.
- Santiagofrom $22
- Calamafrom $23
- Concepciónfrom $23
- Aricafrom $23
- Antofagastafrom $24
Longest direct flights
The longest direct flight from La Serena is to Istanbul at about 17h 4m, followed by Sydney (15h 27m) and Melbourne (15h 24m).
- Istanbul17h 4m
- Sydney15h 27m
- Melbourne15h 24m
- London15h 5m
- Paris15h 4m
Popular destinations from La Serena
Frequently asked questions
- How many destinations are available from La Serena?
- Currently, there are scheduled flights to 6 destinations from the city. All available routes connect La Serena with other major centers in Chile, providing a convenient domestic transport network.
- What are the most popular destinations from La Serena?
- The highest number of flights is to Santiago, with 116 weekly departures. Other popular destinations include Calama (33 flights/week), Antofagasta (29 flights/week), and Concepción (8 flights/week).
- How many airlines fly from La Serena?
- Scheduled air service from the local airport is provided by 3 airlines. The main carriers are Latam Airlines Group, JetSmart, and Sky Airline.
- Which airports serve La Serena?
- The city is served by a single civilian airport — La Florida Airport (LSC). It is conveniently located just 5 kilometers from the city center, allowing for a quick trip to the terminal by taxi or transfer.
- How can I find cheap flights from La Serena?
- To find the best deals, we recommend using the filter system on our website to compare fares from different carriers. Low-cost airlines like JetSmart and Sky Airline often offer the most affordable tickets, especially when booking in advance.
- When is the best time to buy flights from La Serena?
- The optimal time to buy is considered to be 4–6 weeks before your trip. To avoid higher fares, try to book your flights in advance, especially if your travel coincides with public holidays in Chile.