Cheap flights from Santiago to Panama City

Cibao
STI
Tocumen
PTY

Flight deals from Santiago to Panama City

Below you can see the best deals on flights Santiago — Panama City for upcoming dates. Direct and connecting flights from various airlines — compare prices and choose the right ticket.

The lowest price for the next 2 months is on 1 October, from $394.

Top 10 cheap flights from Santiago to Panama City

B6
DL
DL
$ 479

Santiago — Panama City

16:11—12:55
26 Aug 2026
9 h 17 m
2 stops
B6
AV
AV
$ 490

Santiago — Panama City

16:11—00:35
29 Aug 2026
5 h 44 m
2 stops
B6
AV
AV
$ 490

Santiago — Panama City

16:11—09:15
29 Aug 2026
5 h 44 m
2 stops
B6
AV
AV
$ 490

Santiago — Panama City

16:11—14:15
29 Aug 2026
5 h 39 m
2 stops
B6
AV
AV
$ 490

Santiago — Panama City

16:11—00:35
29 Aug 2026
5 h 44 m
2 stops
B6
AV
AV
$ 490

Santiago — Panama City

16:11—00:35
30 Aug 2026
5 h 44 m
2 stops
B6
AV
AV
$ 490

Santiago — Panama City

16:11—09:15
30 Aug 2026
5 h 44 m
2 stops
B6
AV
AV
$ 490

Santiago — Panama City

16:11—14:15
30 Aug 2026
5 h 39 m
2 stops
B6
AV
AV
$ 490

Santiago — Panama City

16:11—00:35
30 Aug 2026
5 h 44 m
2 stops
B6
AV
AV
$ 490

Santiago — Panama City

16:11—00:35
30 Aug 2026
5 h 49 m
2 stops

Prices were found in the last 72 hours and may change — check the exact price when you continue.

About the Santiago — Panama City flight

Looking for cheap flights from Santiago to Panama City? Compare fares from different airlines, check the flight schedule and travel time — and book your Santiago — Panama City ticket online at the best price.

The route has direct flights — around 6 flights per week, flights are operated by Copa Airlines, a nonstop flight takes about 8 h 30 min, the distance between the cities is around 1,501 km.

Planning your trip? You may find our Panama City travel guide, how to get from the airport into town and Panama City weather forecast useful. To catch a low fare, use the low-price calendar and the monthly price chart on this page.

Facts about this route

from $394Min. price
OctoberCheapest
NovemberPeak season
YesDirect flights
1,501 kmDistance
8 h 30 minTravel time
1Airlines
6 / wkFlights

Flight schedule from Santiago to Panama City

The table shows direct flights from Santiago to Panama City on the selected date. The flight takes approximately 8 h 30 min. Regular flights are operated by Copa Airlines. Departures from Cibao International Airport airports, arrivals at Tocumen International Airport and Marcos A. Gelabert International Airport.

For each flight, the following details are shown: departure time (local), arrival city and airport, flight number and airline, terminal or gate, and status. Click on a flight to open its details and go to ticket search. To view flights on a different day, change the date above the table.

Today
Any time
Last update: 08 Aug 2026

Flight ticket prices by day: Santiago — Panama City

Below is a calendar of the lowest flight ticket prices for Santiago — Panama City by day. Pick a convenient date and instantly see the fare. The cheapest flights on this route start from $394 in October, and the most expensive are around $610 in November. If your travel dates are flexible, the calendar will help you find the best price for your preferred period. To view round-trip fares, switch to the "Round trip" tab above the calendar, select your departure date — and the right-hand calendar will highlight the lowest prices for return flights on each day.

 
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Prices by month

Average one-way fares from Santiago to Panama City by month. Tickets are usually cheapest in September (around $478) and priciest in December (about $613) — use the table and chart below to pick the best time to fly.

MonthAverage priceLevelMonthAverage priceLevelMonthAverage priceLevel
Jan$588highMay$490lowSep$478low
Feb$576highJun$515mediumOct$478low
Mar$576highJul$601highNov$527medium
Apr$539mediumAug$588highDec$613high

Some values are estimated based on seasonality.

When to fly

Weather in Panama City: it is warmest in March (up to 30 °C on average) and coolest in November (around 28 °C). The driest month is February.

Tickets are usually cheapest in October and most expensive in November. Compare prices and weather by month in the charts below to pick the best time to fly.

Temperature · Panama City

Dry and wet days · Panama City

Wind speed and direction · Panama City

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How to get the best deal on a Santiago — Panama City ticket

  • Book ahead: fares for Santiago — Panama City are usually lower 3–8 weeks before departure than at the last minute.
  • Play with your dates — Tuesday, Wednesday and Saturday departures are often cheaper than Friday and Sunday.
  • Flights Santiago — Panama City operate on Mondays, Thursdays and Saturdays — keep that in mind when picking your travel dates.
  • The cheapest month to fly to Panama City is usually October — plan your trip around it if your dates are flexible.
  • Compare direct and connecting flights: nonstop is faster, while a connection is sometimes noticeably cheaper.
  • Watch the low-price calendar and the monthly price trend on this page — they make it easier to catch a good date.
  • Travelling light? Pick a cabin-baggage-only fare — tickets without checked luggage are noticeably cheaper.
  • Get to the airport in good time — about 2–3 hours before an international departure and roughly an hour before a domestic one.

Airlines

Flights on the Santiago — Panama City route are operated by 1 airline; Copa Airlines runs the most flights (around 100% of all flights). Compare carriers, flight shares and schedules below.

  • Copa AirlinesCM
    2x/week
    WebsiteFleet: 10316.1M pax/year
    • Direct flight STI → PTY2x/week
      Duration
      2h 35m
      Days
      MTWTFSS
    100.0%Open →

Cities and airports on the Santiago — Panama City route

Flights Santiago — Panama City depart from Cibao International Airport and arrive at Tocumen International Airport and Marcos A. Gelabert International Airport. Below are pages for the cities, countries, and airports on the route: airlines, schedules, and travel guides.

Departure

Santiago

STI
Dominican Republic
About the cityHow to get thereWeatherAll about the country Dominican Republic
Arrival

Panama City

PTY
Panama
About the cityHow to get thereWeatherAll about the country Panama
Departure airports
Arrival airports

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Frequently asked questions about the Santiago — Panama City flight

How long is the flight from Santiago to Panama City?

A nonstop Santiago — Panama City flight takes about 8 h 30 min — the distance between the cities is around 1,501 km.

How far is it from Santiago to Panama City?

The distance from Santiago to Panama City is about 1,501 km, which a nonstop flight covers in around 8 h 30 min.

Are there direct flights from Santiago to Panama City?

Yes, there are nonstop flights Santiago — Panama City — around 6 flights per week.

Which airlines fly from Santiago to Panama City?

Airlines operating Santiago — Panama City include Copa Airlines. See the full list with schedules in the "Airlines" section on this page.

Which airports do Santiago — Panama City flights use?

Flights from Santiago depart from Cibao International Airport, and arrive at Tocumen International Airport, Marcos A. Gelabert International Airport. If a city has more than one airport, check which one your ticket uses before you travel.

How much is a ticket from Santiago to Panama City?

The price of a Santiago — Panama City ticket depends on your travel date, season and demand: it is usually cheapest to fly in October, and most expensive in November. Tickets typically cost between $394 and $610. Check the current lowest fare and low-price calendar on this page.

When is the best time to book flights Santiago — Panama City?

Flights Santiago — Panama City are usually cheaper when booked in advance — a few weeks before departure and away from peak dates; the most budget-friendly month to fly is October. Compare prices by month in the price trend chart on this page.

How can I find the cheapest flights from Santiago to Panama City?

To catch a low fare Santiago — Panama City, book a few weeks in advance, keep your dates flexible, and compare airlines and connecting options. The low-price calendar and monthly price chart on this page show the cheapest days and months at a glance: the most budget-friendly month to fly is usually October.

How early should I arrive at the airport?

For international flights, plan to be at the airport about 2–3 hours before departure, and around an hour before a domestic flight. Allow extra time during busy travel seasons and at large hubs, where check-in and security lines can be longer.

Where else you can fly from Santiago

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New York CityMiamiBostonFort LauderdalePhiladelphiaOrlandoSan JuanMadrid

Where else you can fly from Panama City

See all
BogotaMedellínSan JoséMiamiPunta CanaMexico CityNew York CityLimaOrlandoCancunQuitoBuenos AiresSantiagoGuayaquilGuatemala CitySao PauloSanto DomingoSan SalvadorCordobaCaliCartagenaWashington, D.C.Los AngelesHavanaChicagoMontevideoHoustonCaracasRio de JaneiroDavidAsunciónManaguaSan JuanTorontoWillemstadTegucigalpaAtlantaOranjestadMadridPereira

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