Cheap flights from Panama City to Santo Domingo

Tocumen
PTY
Las Americas
SDQ

Flight deals from Panama City to Santo Domingo

Below you can see the best deals on flights Panama City — Santo Domingo for upcoming dates. Direct and connecting flights from various airlines — compare prices and choose the right ticket.

The lowest price for the next 2 months is on 31 August, from $314.

Top 10 cheap flights from Panama City to Santo Domingo

CM
DM
$ 314

Panama City — Santo Domingo

10:25—23:49
31 Aug 2026
36 h 24 m
1 stop
CM
DM
$ 314

Panama City — Santo Domingo

08:11—23:49
31 Aug 2026
38 h 38 m
1 stop
CM
DM
$ 314

Panama City — Santo Domingo

10:25—23:49
8 Sep 2026
12 h 24 m
1 stop
CM
DM
$ 314

Panama City — Santo Domingo

08:11—23:49
8 Sep 2026
14 h 38 m
1 stop
CM
DM
$ 314

Panama City — Santo Domingo

07:24—23:49
8 Sep 2026
15 h 25 m
1 stop
CM
DM
$ 314

Panama City — Santo Domingo

21:45—23:49
7 Sep 2026
25 h 4 m
1 stop
CM
DM
$ 314

Panama City — Santo Domingo

10:25—23:49
7 Sep 2026
36 h 24 m
1 stop
CM
DM
$ 314

Panama City — Santo Domingo

08:11—23:49
7 Sep 2026
38 h 38 m
1 stop
CM
DM
$ 314

Panama City — Santo Domingo

07:24—23:49
7 Sep 2026
39 h 25 m
1 stop
CM
DM
$ 314

Panama City — Santo Domingo

18:35—13:59
2 Sep 2026
18 h 24 m
1 stop

Prices were found in the last 72 hours and may change — check the exact price when you continue.

About the Panama City — Santo Domingo flight

Looking for cheap flights from Panama City to Santo Domingo? Compare fares from different airlines, check the flight schedule and travel time — and book your Panama City — Santo Domingo ticket online at the best price.

The route has direct flights — around 69 flights per week, flights are operated by Copa Airlines, a nonstop flight takes about 2 h 30 min, the distance between the cities is around 1,474 km.

Planning your trip? You may find our Santo Domingo travel guide, how to get from the airport into town and Santo Domingo weather forecast useful. To catch a low fare, use the low-price calendar and the monthly price chart on this page.

Facts about this route

from $297Min. price
JanuaryCheapest
OctoberPeak season
YesDirect flights
1,474 kmDistance
2 h 30 minTravel time
1Airlines
69 / wkFlights

Flight schedule from Panama City to Santo Domingo

The table shows direct flights from Panama City to Santo Domingo on the selected date. The flight takes approximately 2 h 30 min. Regular flights are operated by Copa Airlines. Departures from Tocumen International Airport and Marcos A. Gelabert International Airport airports, arrivals at Las Americas International Airport and La Isabela International Airport.

For each flight, the following details are shown: departure time (local), arrival city and airport, flight number and airline, terminal or gate, and status. Click on a flight to open its details and go to ticket search. To view flights on a different day, change the date above the table.

Today
Any time
Last update: 13 Aug 2026

Flight ticket prices by day: Panama City — Santo Domingo

Below is a calendar of the lowest flight ticket prices for Panama City — Santo Domingo by day. Pick a convenient date and instantly see the fare. The cheapest flights on this route start from $297 in January, and the most expensive are around $333 in October. If your travel dates are flexible, the calendar will help you find the best price for your preferred period. To view round-trip fares, switch to the "Round trip" tab above the calendar, select your departure date — and the right-hand calendar will highlight the lowest prices for return flights on each day.

 
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Prices by month

Average one-way fares from Panama City to Santo Domingo by month. Tickets are usually cheapest in September (around $195) and priciest in December (about $292) — use the table and chart below to pick the best time to fly.

MonthAverage priceLevelMonthAverage priceLevelMonthAverage priceLevel
Jan$274highMay$204lowSep$195low
Feb$247mediumJun$230mediumOct$222medium
Mar$270highJul$261highNov$257high
Apr$239mediumAug$226mediumDec$292high

Some values are estimated based on seasonality.

When to fly

Weather in Santo Domingo: it is warmest in August (up to 31 °C on average) and coolest in January (around 28 °C). The driest month is January.

Tickets are usually cheapest in January and most expensive in October. Compare prices and weather by month in the charts below to pick the best time to fly.

Temperature · Santo Domingo

Dry and wet days · Santo Domingo

Wind speed and direction · Santo Domingo

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How to get the best deal on a Panama City — Santo Domingo ticket

  • Book ahead: fares for Panama City — Santo Domingo are usually lower 3–8 weeks before departure than at the last minute.
  • Play with your dates — Tuesday, Wednesday and Saturday departures are often cheaper than Friday and Sunday.
  • Panama City is served by more than one airport — compare fares and travel time to each before you book.
  • The cheapest month to fly to Santo Domingo is usually January — plan your trip around it if your dates are flexible.
  • Compare direct and connecting flights: nonstop is faster, while a connection is sometimes noticeably cheaper.
  • Watch the low-price calendar and the monthly price trend on this page — they make it easier to catch a good date.
  • Travelling light? Pick a cabin-baggage-only fare — tickets without checked luggage are noticeably cheaper.
  • Get to the airport in good time — about 2–3 hours before an international departure and roughly an hour before a domestic one.

Airlines

Flights on the Panama City — Santo Domingo route are operated by 1 airline; Copa Airlines runs the most flights (around 100% of all flights). Compare carriers, flight shares and schedules below.

  • Copa AirlinesCM
    23x/week
    WebsiteFleet: 10316.1M pax/year
    • Direct flight PTY → SDQ23x/week
      Duration
      2h 31m
      Days
      MTWTFSS
    100.0%Open →

Cities and airports on the Panama City — Santo Domingo route

Flights Panama City — Santo Domingo depart from Tocumen International Airport and Marcos A. Gelabert International Airport and arrive at Las Americas International Airport and La Isabela International Airport. Below are pages for the cities, countries, and airports on the route: airlines, schedules, and travel guides.

Departure

Panama City

PTY
Panama
About the cityHow to get thereWeatherAll about the country Panama
Arrival

Santo Domingo

SDQ
Dominican Republic
About the cityHow to get thereWeatherAll about the country Dominican Republic
Departure airports
Arrival airports

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Frequently asked questions about the Panama City — Santo Domingo flight

How long is the flight from Panama City to Santo Domingo?

A nonstop Panama City — Santo Domingo flight takes about 2 h 30 min — the distance between the cities is around 1,474 km.

How far is it from Panama City to Santo Domingo?

The distance from Panama City to Santo Domingo is about 1,474 km, which a nonstop flight covers in around 2 h 30 min.

Are there direct flights from Panama City to Santo Domingo?

Yes, there are nonstop flights Panama City — Santo Domingo — around 69 flights per week.

Which airlines fly from Panama City to Santo Domingo?

Airlines operating Panama City — Santo Domingo include Copa Airlines. See the full list with schedules in the "Airlines" section on this page.

Which airports do Panama City — Santo Domingo flights use?

Flights from Panama City depart from Tocumen International Airport, Marcos A. Gelabert International Airport, and arrive at Las Americas International Airport, La Isabela International Airport. If a city has more than one airport, check which one your ticket uses before you travel.

How much is a ticket from Panama City to Santo Domingo?

The price of a Panama City — Santo Domingo ticket depends on your travel date, season and demand: it is usually cheapest to fly in January, and most expensive in October. Tickets typically cost between $297 and $333. Check the current lowest fare and low-price calendar on this page.

When is the best time to book flights Panama City — Santo Domingo?

Flights Panama City — Santo Domingo are usually cheaper when booked in advance — a few weeks before departure and away from peak dates; the most budget-friendly month to fly is January. Compare prices by month in the price trend chart on this page.

How can I find the cheapest flights from Panama City to Santo Domingo?

To catch a low fare Panama City — Santo Domingo, book a few weeks in advance, keep your dates flexible, and compare airlines and connecting options. The low-price calendar and monthly price chart on this page show the cheapest days and months at a glance: the most budget-friendly month to fly is usually January.

How early should I arrive at the airport?

For international flights, plan to be at the airport about 2–3 hours before departure, and around an hour before a domestic flight. Allow extra time during busy travel seasons and at large hubs, where check-in and security lines can be longer.

Where else you can fly from Panama City

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Where else you can fly from Santo Domingo

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New York CitySan JuanOrlandoMiamiMadridBogotaBostonPhiladelphiaFort LauderdaleMexico CityAtlantaMedellínGuatemala CityFort-de-FranceSan JoséPointe-à-PitrePhilipsburgKingstonLimaWillemstadTampaCartagenaBuenos AiresPunta CanaParisFrankfurt am MainOranjestadTortolaSan SalvadorProvidencialesHavanaLondonTorontoLos AngelesCaracas

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