Cheap flights from Santo Domingo to Panama City

Las Americas
SDQ
Tocumen
PTY

Flight deals from Santo Domingo to Panama City

Below you can see the best deals on flights Santo Domingo — Panama City for upcoming dates. Direct and connecting flights from various airlines — compare prices and choose the right ticket.

The lowest price for the next 2 months is on 22 September, from $252.

Top 10 cheap flights from Santo Domingo to Panama City

AV
AV
$ 294

Santo Domingo — Panama City

18:50—00:35
20 Aug 2026
6 h 45 m
1 stop
AV
AV
$ 294

Santo Domingo — Panama City

12:45—00:35
20 Aug 2026
12 h 50 m
1 stop
AV
AV
$ 294

Santo Domingo — Panama City

18:50—14:15
20 Aug 2026
20 h 25 m
1 stop
AV
AV
$ 294

Santo Domingo — Panama City

12:45—09:15
20 Aug 2026
21 h 30 m
1 stop
AV
AV
$ 294

Santo Domingo — Panama City

18:50—17:00
20 Aug 2026
23 h 10 m
1 stop
AV
AV
$ 294

Santo Domingo — Panama City

12:45—14:15
20 Aug 2026
26 h 30 m
1 stop
AV
AV
$ 294

Santo Domingo — Panama City

18:50—00:35
28 Aug 2026
6 h 45 m
1 stop
AV
AV
$ 294

Santo Domingo — Panama City

12:45—00:35
28 Aug 2026
12 h 50 m
1 stop
AV
AV
$ 294

Santo Domingo — Panama City

18:50—09:15
28 Aug 2026
15 h 25 m
1 stop
AV
AV
$ 294

Santo Domingo — Panama City

18:50—14:15
28 Aug 2026
20 h 25 m
1 stop

Prices were found in the last 72 hours and may change — check the exact price when you continue.

About the Santo Domingo — Panama City flight

Looking for cheap flights from Santo Domingo to Panama City? Compare fares from different airlines, check the flight schedule and travel time — and book your Santo Domingo — Panama City ticket online at the best price.

The route has direct flights — around 69 flights per week, flights are operated by Copa Airlines, a nonstop flight takes about 2 h 32 min, the distance between the cities is around 1,474 km.

Planning your trip? You may find our Panama City travel guide, how to get from the airport into town and Panama City weather forecast useful. To catch a low fare, use the low-price calendar and the monthly price chart on this page.

Facts about this route

from $242Min. price
OctoberCheapest
JunePeak season
YesDirect flights
1,474 kmDistance
2 h 32 minTravel time
1Airlines
69 / wkFlights

Flight schedule from Santo Domingo to Panama City

The table shows direct flights from Santo Domingo to Panama City on the selected date. The flight takes approximately 2 h 32 min. Regular flights are operated by Copa Airlines. Departures from Las Americas International Airport and La Isabela International Airport airports, arrivals at Tocumen International Airport and Marcos A. Gelabert International Airport.

For each flight, the following details are shown: departure time (local), arrival city and airport, flight number and airline, terminal or gate, and status. Click on a flight to open its details and go to ticket search. To view flights on a different day, change the date above the table.

Today
Any time
Last update: 13 Aug 2026

Flight ticket prices by day: Santo Domingo — Panama City

Below is a calendar of the lowest flight ticket prices for Santo Domingo — Panama City by day. Pick a convenient date and instantly see the fare. The cheapest flights on this route start from $242 in October, and the most expensive are around $309 in June. If your travel dates are flexible, the calendar will help you find the best price for your preferred period. To view round-trip fares, switch to the "Round trip" tab above the calendar, select your departure date — and the right-hand calendar will highlight the lowest prices for return flights on each day.

 
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Prices by month

Average one-way fares from Santo Domingo to Panama City by month. Tickets are usually cheapest in September (around $363) and priciest in December (about $544) — use the table and chart below to pick the best time to fly.

MonthAverage priceLevelMonthAverage priceLevelMonthAverage priceLevel
Jan$508highMay$411lowSep$363low
Feb$496highJun$435mediumOct$363low
Mar$483highJul$459highNov$411medium
Apr$459mediumAug$435mediumDec$544high

Some values are estimated based on seasonality.

When to fly

Weather in Panama City: it is warmest in March (up to 30 °C on average) and coolest in November (around 28 °C). The driest month is February.

Tickets are usually cheapest in October and most expensive in June. Compare prices and weather by month in the charts below to pick the best time to fly.

Temperature · Panama City

Dry and wet days · Panama City

Wind speed and direction · Panama City

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How to get the best deal on a Santo Domingo — Panama City ticket

  • Book ahead: fares for Santo Domingo — Panama City are usually lower 3–8 weeks before departure than at the last minute.
  • Play with your dates — Tuesday, Wednesday and Saturday departures are often cheaper than Friday and Sunday.
  • Santo Domingo is served by more than one airport — compare fares and travel time to each before you book.
  • The cheapest month to fly to Panama City is usually October — plan your trip around it if your dates are flexible.
  • Compare direct and connecting flights: nonstop is faster, while a connection is sometimes noticeably cheaper.
  • Watch the low-price calendar and the monthly price trend on this page — they make it easier to catch a good date.
  • Travelling light? Pick a cabin-baggage-only fare — tickets without checked luggage are noticeably cheaper.
  • Get to the airport in good time — about 2–3 hours before an international departure and roughly an hour before a domestic one.

Airlines

Flights on the Santo Domingo — Panama City route are operated by 1 airline; Copa Airlines runs the most flights (around 100% of all flights). Compare carriers, flight shares and schedules below.

  • Copa AirlinesCM
    23x/week
    WebsiteFleet: 10316.1M pax/year
    • Direct flight SDQ → PTY23x/week
      Duration
      2h 32m
      Days
      MTWTFSS
    100.0%Open →

Cities and airports on the Santo Domingo — Panama City route

Flights Santo Domingo — Panama City depart from Las Americas International Airport and La Isabela International Airport and arrive at Tocumen International Airport and Marcos A. Gelabert International Airport. Below are pages for the cities, countries, and airports on the route: airlines, schedules, and travel guides.

Departure

Santo Domingo

SDQ
Dominican Republic
About the cityHow to get thereWeatherAll about the country Dominican Republic
Arrival

Panama City

PTY
Panama
About the cityHow to get thereWeatherAll about the country Panama
Departure airports
Arrival airports

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Frequently asked questions about the Santo Domingo — Panama City flight

How long is the flight from Santo Domingo to Panama City?

A nonstop Santo Domingo — Panama City flight takes about 2 h 32 min — the distance between the cities is around 1,474 km.

How far is it from Santo Domingo to Panama City?

The distance from Santo Domingo to Panama City is about 1,474 km, which a nonstop flight covers in around 2 h 32 min.

Are there direct flights from Santo Domingo to Panama City?

Yes, there are nonstop flights Santo Domingo — Panama City — around 69 flights per week.

Which airlines fly from Santo Domingo to Panama City?

Airlines operating Santo Domingo — Panama City include Copa Airlines. See the full list with schedules in the "Airlines" section on this page.

Which airports do Santo Domingo — Panama City flights use?

Flights from Santo Domingo depart from Las Americas International Airport, La Isabela International Airport, and arrive at Tocumen International Airport, Marcos A. Gelabert International Airport. If a city has more than one airport, check which one your ticket uses before you travel.

How much is a ticket from Santo Domingo to Panama City?

The price of a Santo Domingo — Panama City ticket depends on your travel date, season and demand: it is usually cheapest to fly in October, and most expensive in June. Tickets typically cost between $242 and $309. Check the current lowest fare and low-price calendar on this page.

When is the best time to book flights Santo Domingo — Panama City?

Flights Santo Domingo — Panama City are usually cheaper when booked in advance — a few weeks before departure and away from peak dates; the most budget-friendly month to fly is October. Compare prices by month in the price trend chart on this page.

How can I find the cheapest flights from Santo Domingo to Panama City?

To catch a low fare Santo Domingo — Panama City, book a few weeks in advance, keep your dates flexible, and compare airlines and connecting options. The low-price calendar and monthly price chart on this page show the cheapest days and months at a glance: the most budget-friendly month to fly is usually October.

How early should I arrive at the airport?

For international flights, plan to be at the airport about 2–3 hours before departure, and around an hour before a domestic flight. Allow extra time during busy travel seasons and at large hubs, where check-in and security lines can be longer.

Where else you can fly from Santo Domingo

See all
New York CitySan JuanOrlandoMiamiMadridBogotaBostonPhiladelphiaFort LauderdaleMexico CityAtlantaMedellínGuatemala CityFort-de-FranceSan JoséPointe-à-PitrePhilipsburgKingstonLimaWillemstadTampaCartagenaBuenos AiresPunta CanaParisFrankfurt am MainOranjestadTortolaSan SalvadorProvidencialesHavanaLondonTorontoLos AngelesCaracas

Where else you can fly from Panama City

See all
BogotaMedellínSan JoséMiamiPunta CanaMexico CityNew York CityLimaOrlandoCancunQuitoBuenos AiresSantiagoGuayaquilGuatemala CitySao PauloSan SalvadorCordobaCaliCartagenaWashington, D.C.Los AngelesHavanaChicagoHoustonMontevideoDavidRio de JaneiroCaracasAsunciónManaguaSan JuanTorontoWillemstadTegucigalpaOranjestadAtlantaMadridPereiraTampa

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