Cheap flights from Panama City to Santa Cruz de la Sierra

Tocumen
PTY
El Trompillo
SRZ

Flight deals from Panama City to Santa Cruz de la Sierra

Below you can see the best deals on flights Panama City — Santa Cruz de la Sierra for upcoming dates. Direct and connecting flights from various airlines — compare prices and choose the right ticket.

The lowest price for the next 2 months is on 5 October, from $341.

Top 10 cheap flights from Panama City to Santa Cruz de la Sierra

AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

17:55—02:30
20 Sep 2026
7 h 35 m
1 stop
AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

15:10—02:30
20 Sep 2026
10 h 20 m
1 stop
AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

10:10—02:30
20 Sep 2026
15 h 20 m
1 stop
AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

04:25—02:30
20 Sep 2026
21 h 5 m
1 stop
AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

17:55—02:30
15 Sep 2026
7 h 35 m
1 stop
AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

15:10—02:30
15 Sep 2026
10 h 20 m
1 stop
AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

10:10—02:30
15 Sep 2026
15 h 20 m
1 stop
AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

04:25—02:30
15 Sep 2026
21 h 5 m
1 stop
AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

17:55—02:30
6 Sep 2026
7 h 35 m
1 stop
AV
AV
$ 356

Panama City — Santa Cruz de la Sierra

15:10—02:30
6 Sep 2026
10 h 20 m
1 stop

Prices were found in the last 72 hours and may change — check the exact price when you continue.

About the Panama City — Santa Cruz de la Sierra flight

Looking for cheap flights from Panama City to Santa Cruz de la Sierra? Compare fares from different airlines, check the flight schedule and travel time — and book your Panama City — Santa Cruz de la Sierra ticket online at the best price.

The route has direct flights — around 22 flights per week, flights are operated by Copa Airlines, a nonstop flight takes about 5 h, the distance between the cities is around 3,464 km.

Planning your trip? You may find our Santa Cruz de la Sierra travel guide, how to get from the airport into town and Santa Cruz de la Sierra weather forecast useful. To catch a low fare, use the low-price calendar and the monthly price chart on this page.

Facts about this route

from $341Min. price
OctoberCheapest
JulyPeak season
YesDirect flights
3,464 kmDistance
5 hTravel time
1Airlines
22 / wkFlights

Flight schedule from Panama City to Santa Cruz de la Sierra

The table shows direct flights from Panama City to Santa Cruz de la Sierra on the selected date. The flight takes approximately 5 h. Regular flights are operated by Copa Airlines. Departures from Tocumen International Airport and Marcos A. Gelabert International Airport airports, arrivals at Viru Viru International Airport.

For each flight, the following details are shown: departure time (local), arrival city and airport, flight number and airline, terminal or gate, and status. Click on a flight to open its details and go to ticket search. To view flights on a different day, change the date above the table.

Today
Any time
Last update: 25 Aug 2026

Flight ticket prices by day: Panama City — Santa Cruz de la Sierra

Below is a calendar of the lowest flight ticket prices for Panama City — Santa Cruz de la Sierra by day. Pick a convenient date and instantly see the fare. The cheapest flights on this route start from $341 in October, and the most expensive are around $450 in July. If your travel dates are flexible, the calendar will help you find the best price for your preferred period. To view round-trip fares, switch to the "Round trip" tab above the calendar, select your departure date — and the right-hand calendar will highlight the lowest prices for return flights on each day.

 
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Prices by month

Average one-way fares from Panama City to Santa Cruz de la Sierra by month. Tickets are usually cheapest in May (around $444) and priciest in December (about $564) — use the table and chart below to pick the best time to fly.

MonthAverage priceLevelMonthAverage priceLevelMonthAverage priceLevel
Jan$540highMay$444lowSep$480medium
Feb$480mediumJun$528highOct$468medium
Mar$492mediumJul$552highNov$456low
Apr$468mediumAug$516highDec$564high

Some values are estimated based on seasonality.

When to fly

Weather in Santa Cruz de la Sierra: it is warmest in October (up to 32 °C on average) and coolest in June (around 25 °C). The driest month is August.

Tickets are usually cheapest in October and most expensive in July. Compare prices and weather by month in the charts below to pick the best time to fly.

Temperature · Santa Cruz de la Sierra

Dry and wet days · Santa Cruz de la Sierra

Wind speed and direction · Santa Cruz de la Sierra

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How to get the best deal on a Panama City — Santa Cruz de la Sierra ticket

  • Book ahead: fares for Panama City — Santa Cruz de la Sierra are usually lower 3–8 weeks before departure than at the last minute.
  • Play with your dates — Tuesday, Wednesday and Saturday departures are often cheaper than Friday and Sunday.
  • Panama City is served by more than one airport — compare fares and travel time to each before you book.
  • The cheapest month to fly to Santa Cruz de la Sierra is usually October — plan your trip around it if your dates are flexible.
  • Compare direct and connecting flights: nonstop is faster, while a connection is sometimes noticeably cheaper.
  • Watch the low-price calendar and the monthly price trend on this page — they make it easier to catch a good date.
  • Travelling light? Pick a cabin-baggage-only fare — tickets without checked luggage are noticeably cheaper.
  • Get to the airport in good time — about 2–3 hours before an international departure and roughly an hour before a domestic one.

Airlines

Flights on the Panama City — Santa Cruz de la Sierra route are operated by 1 airline; Copa Airlines runs the most flights (around 100% of all flights). Compare carriers, flight shares and schedules below.

  • Copa AirlinesCM
    7x/week
    WebsiteFleet: 10316.1M pax/year
    • Direct flight PTY → VVI7x/week
      Duration
      4h 59m
      Days
      MTWTFSS
    100.0%Open →

Cities and airports on the Panama City — Santa Cruz de la Sierra route

Flights Panama City — Santa Cruz de la Sierra depart from Tocumen International Airport and Marcos A. Gelabert International Airport and arrive at Viru Viru International Airport. Below are pages for the cities, countries, and airports on the route: airlines, schedules, and travel guides.

Departure

Panama City

PTY
Panama
About the cityHow to get thereWeatherAll about the country Panama
Arrival

Santa Cruz de la Sierra

SRZ
Bolivia
About the cityHow to get thereWeatherAll about the country Bolivia
Departure airports
Arrival airports

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Frequently asked questions about the Panama City — Santa Cruz de la Sierra flight

How long is the flight from Panama City to Santa Cruz de la Sierra?

A nonstop Panama City — Santa Cruz de la Sierra flight takes about 5 h — the distance between the cities is around 3,464 km.

How far is it from Panama City to Santa Cruz de la Sierra?

The distance from Panama City to Santa Cruz de la Sierra is about 3,464 km, which a nonstop flight covers in around 5 h.

Are there direct flights from Panama City to Santa Cruz de la Sierra?

Yes, there are nonstop flights Panama City — Santa Cruz de la Sierra — around 22 flights per week.

Which airlines fly from Panama City to Santa Cruz de la Sierra?

Airlines operating Panama City — Santa Cruz de la Sierra include Copa Airlines. See the full list with schedules in the "Airlines" section on this page.

Which airports do Panama City — Santa Cruz de la Sierra flights use?

Flights from Panama City depart from Tocumen International Airport, Marcos A. Gelabert International Airport, and arrive at Viru Viru International Airport. If a city has more than one airport, check which one your ticket uses before you travel.

How much is a ticket from Panama City to Santa Cruz de la Sierra?

The price of a Panama City — Santa Cruz de la Sierra ticket depends on your travel date, season and demand: it is usually cheapest to fly in October, and most expensive in July. Tickets typically cost between $341 and $450. Check the current lowest fare and low-price calendar on this page.

When is the best time to book flights Panama City — Santa Cruz de la Sierra?

Flights Panama City — Santa Cruz de la Sierra are usually cheaper when booked in advance — a few weeks before departure and away from peak dates; the most budget-friendly month to fly is October. Compare prices by month in the price trend chart on this page.

How can I find the cheapest flights from Panama City to Santa Cruz de la Sierra?

To catch a low fare Panama City — Santa Cruz de la Sierra, book a few weeks in advance, keep your dates flexible, and compare airlines and connecting options. The low-price calendar and monthly price chart on this page show the cheapest days and months at a glance: the most budget-friendly month to fly is usually October.

How early should I arrive at the airport?

For international flights, plan to be at the airport about 2–3 hours before departure, and around an hour before a domestic flight. Allow extra time during busy travel seasons and at large hubs, where check-in and security lines can be longer.

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