Cheap flights from Santiago to Santa Cruz de la Sierra

Arturo Merino Benítez
SCL
El Trompillo
SRZ

Flight deals from Santiago to Santa Cruz de la Sierra

Below you can see the best deals on flights Santiago — Santa Cruz de la Sierra for upcoming dates. Direct and connecting flights from various airlines — compare prices and choose the right ticket.

The lowest price for the next 2 months is on 16 September, from $149.

Top 10 cheap flights from Santiago to Santa Cruz de la Sierra

OB
$ 158

Santiago — Santa Cruz de la Sierra

02:25—04:40
23 Sep 2026
3 h 15 m
Direct flight
OB
$ 158

Santiago — Santa Cruz de la Sierra

02:25—04:40
9 Sep 2026
3 h 15 m
Direct flight
OB
$ 158

Santiago — Santa Cruz de la Sierra

02:25—04:40
19 Sep 2026
3 h 15 m
Direct flight
OB
$ 158

Santiago — Santa Cruz de la Sierra

01:25—04:40
2 Sep 2026
3 h 15 m
Direct flight
AR
AR
$ 171

Santiago — Santa Cruz de la Sierra

14:35—01:10
18 Sep 2026
11 h 35 m
1 stop
AR
AR
$ 171

Santiago — Santa Cruz de la Sierra

09:15—01:10
18 Sep 2026
16 h 55 m
1 stop
OB
$ 180

Santiago — Santa Cruz de la Sierra

01:25—04:40
26 Aug 2026
3 h 15 m
Direct flight
OB
$ 180

Santiago — Santa Cruz de la Sierra

01:25—04:40
29 Aug 2026
3 h 15 m
Direct flight
OB
$ 180

Santiago — Santa Cruz de la Sierra

01:25—04:40
5 Sep 2026
3 h 15 m
Direct flight
AR
AR
$ 192

Santiago — Santa Cruz de la Sierra

09:15—01:10
21 Sep 2026
16 h 55 m
1 stop

Prices were found in the last 72 hours and may change — check the exact price when you continue.

About the Santiago — Santa Cruz de la Sierra flight

Looking for cheap flights from Santiago to Santa Cruz de la Sierra? Compare fares from different airlines, check the flight schedule and travel time — and book your Santiago — Santa Cruz de la Sierra ticket online at the best price.

The route has direct flights — around 11 flights per week, flights are operated by Boliviana de Aviacion, Latam Airlines Group, a nonstop flight takes about 8 h 25 min, the distance between the cities is around 1,888 km.

Planning your trip? You may find our Santa Cruz de la Sierra travel guide, how to get from the airport into town and Santa Cruz de la Sierra weather forecast useful. To catch a low fare, use the low-price calendar and the monthly price chart on this page.

Facts about this route

from $149Min. price
SeptemberCheapest
JanuaryPeak season
YesDirect flights
1,888 kmDistance
8 h 25 minTravel time
2Airlines
11 / wkFlights

Flight schedule from Santiago to Santa Cruz de la Sierra

The table shows direct flights from Santiago to Santa Cruz de la Sierra on the selected date. The flight takes approximately 8 h 25 min. Regular flights are operated by Boliviana de Aviacion and Latam Airlines Group. Departures from Arturo Merino Benitez Airport airports, arrivals at Viru Viru International Airport.

For each flight, the following details are shown: departure time (local), arrival city and airport, flight number and airline, terminal or gate, and status. Click on a flight to open its details and go to ticket search. To view flights on a different day, change the date above the table.

Wed, 26 August
Any time
Last update: 25 Aug 2026

Flight ticket prices by day: Santiago — Santa Cruz de la Sierra

Below is a calendar of the lowest flight ticket prices for Santiago — Santa Cruz de la Sierra by day. Pick a convenient date and instantly see the fare. The cheapest flights on this route start from $149 in September, and the most expensive are around $203 in January. If your travel dates are flexible, the calendar will help you find the best price for your preferred period. To view round-trip fares, switch to the "Round trip" tab above the calendar, select your departure date — and the right-hand calendar will highlight the lowest prices for return flights on each day.

 
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Prices by month

Average one-way fares from Santiago to Santa Cruz de la Sierra by month. Tickets are usually cheapest in April (around $264) and priciest in July (about $384) — use the table and chart below to pick the best time to fly.

MonthAverage priceLevelMonthAverage priceLevelMonthAverage priceLevel
Jan$372highMay$300mediumSep$276low
Feb$324mediumJun$312mediumOct$264low
Mar$276lowJul$384highNov$288medium
Apr$264lowAug$348highDec$372high

Some values are estimated based on seasonality.

When to fly

Weather in Santa Cruz de la Sierra: it is warmest in October (up to 32 °C on average) and coolest in June (around 25 °C). The driest month is August.

Tickets are usually cheapest in September and most expensive in January. Compare prices and weather by month in the charts below to pick the best time to fly.

Temperature · Santa Cruz de la Sierra

Dry and wet days · Santa Cruz de la Sierra

Wind speed and direction · Santa Cruz de la Sierra

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How to get the best deal on a Santiago — Santa Cruz de la Sierra ticket

  • Book ahead: fares for Santiago — Santa Cruz de la Sierra are usually lower 3–8 weeks before departure than at the last minute.
  • Play with your dates — Tuesday, Wednesday and Saturday departures are often cheaper than Friday and Sunday.
  • Flights Santiago — Santa Cruz de la Sierra operate on Mondays, Wednesdays, Thursdays and Saturdays — keep that in mind when picking your travel dates.
  • The cheapest month to fly to Santa Cruz de la Sierra is usually September — plan your trip around it if your dates are flexible.
  • Compare direct and connecting flights: nonstop is faster, while a connection is sometimes noticeably cheaper.
  • Watch the low-price calendar and the monthly price trend on this page — they make it easier to catch a good date.
  • Travelling light? Pick a cabin-baggage-only fare — tickets without checked luggage are noticeably cheaper.
  • Get to the airport in good time — about 2–3 hours before an international departure and roughly an hour before a domestic one.

Airlines

Flights on the Santiago — Santa Cruz de la Sierra route are operated by 2 airlines; Boliviana de Aviacion runs the most flights (around 55% of all flights). Compare carriers, flight shares and schedules below.

  • Boliviana de AviacionOB
    2x/week
    WebsiteFleet: 204M pax/year
    • Direct flight SCL → VVI2x/week
      Duration
      3h 25m
      Days
      MTWTFSS
    54.5%Open →
  • Latam Airlines GroupLA
    2x/week
    WebsiteFleet: 34782M pax/year
    • Direct flight SCL → VVI2x/week
      Duration
      4h 7m
      Days
      MTWTFSS
    45.5%Open →

Cities and airports on the Santiago — Santa Cruz de la Sierra route

Flights Santiago — Santa Cruz de la Sierra depart from Arturo Merino Benitez Airport and arrive at Viru Viru International Airport. Below are pages for the cities, countries, and airports on the route: airlines, schedules, and travel guides.

Departure

Santiago

SCL
Chile
About the cityHow to get thereWeatherAll about the country Chile
Arrival

Santa Cruz de la Sierra

SRZ
Bolivia
About the cityHow to get thereWeatherAll about the country Bolivia
Departure airports
Arrival airports

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Frequently asked questions about the Santiago — Santa Cruz de la Sierra flight

How long is the flight from Santiago to Santa Cruz de la Sierra?

A nonstop Santiago — Santa Cruz de la Sierra flight takes about 8 h 25 min — the distance between the cities is around 1,888 km.

How far is it from Santiago to Santa Cruz de la Sierra?

The distance from Santiago to Santa Cruz de la Sierra is about 1,888 km, which a nonstop flight covers in around 8 h 25 min.

Are there direct flights from Santiago to Santa Cruz de la Sierra?

Yes, there are nonstop flights Santiago — Santa Cruz de la Sierra — around 11 flights per week.

Which airlines fly from Santiago to Santa Cruz de la Sierra?

Airlines operating Santiago — Santa Cruz de la Sierra include Boliviana de Aviacion, Latam Airlines Group. See the full list with schedules in the "Airlines" section on this page.

Which airports do Santiago — Santa Cruz de la Sierra flights use?

Flights from Santiago depart from Arturo Merino Benitez Airport, and arrive at Viru Viru International Airport. If a city has more than one airport, check which one your ticket uses before you travel.

How much is a ticket from Santiago to Santa Cruz de la Sierra?

The price of a Santiago — Santa Cruz de la Sierra ticket depends on your travel date, season and demand: it is usually cheapest to fly in September, and most expensive in January. Tickets typically cost between $149 and $203. Check the current lowest fare and low-price calendar on this page.

When is the best time to book flights Santiago — Santa Cruz de la Sierra?

Flights Santiago — Santa Cruz de la Sierra are usually cheaper when booked in advance — a few weeks before departure and away from peak dates; the most budget-friendly month to fly is September. Compare prices by month in the price trend chart on this page.

How can I find the cheapest flights from Santiago to Santa Cruz de la Sierra?

To catch a low fare Santiago — Santa Cruz de la Sierra, book a few weeks in advance, keep your dates flexible, and compare airlines and connecting options. The low-price calendar and monthly price chart on this page show the cheapest days and months at a glance: the most budget-friendly month to fly is usually September.

How early should I arrive at the airport?

For international flights, plan to be at the airport about 2–3 hours before departure, and around an hour before a domestic flight. Allow extra time during busy travel seasons and at large hubs, where check-in and security lines can be longer.

Where else you can fly from Santiago

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Buenos AiresCalamaAntofagastaLimaSao PauloConcepciónPuerto MonttLa SerenaRio de JaneiroIquiqueBogotaCopiapoPunta ArenasPanama CityMadridFlorianopolisAricaTemucoMendozaMiamiBalmacedaMontevideoMexico CityHanga RoaSydneyOsornoHoustonBarilocheCuscoBelo HorizonteBrasiliaDallasAtlantaLos AngelesNew York CityTorontoCordobaParisGuayaquilBarcelona

Where else you can fly from Santa Cruz de la Sierra

See all
CochabambaLa PazSucreSao PauloBuenos AiresTarijaLimaPanama CityAsunciónMiamiMadridBogotaRio de JaneiroIquiqueCaracasBarcelonaOruroWashington, D.C.

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